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In this thesis, A6K, A9K, G(IIKK)3I-NH2, the fluorescently FITC-labelled A9K and G(IIKK)3I-NH2 amphiphilic cationic peptides have been intensively studied to evaluate their interactions with eukaryotic cell and in particular their selectivity towards cancer cells. A possible usage of these cationic peptides as delivery vectors of small nucleic acids molecules was also investigated.
The use of peptides as drugs has been hampered due to, in part, poor stability in vivo. To address this issue, heteroaromatics have been investigated in an attempt to improve enzymatic stability. In particular, pentafluoropyridine has emerged as an interesting tool for peptide modification due to its reactivity towards nucleophilic peptide side chains.
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LEAR, SAM (2016) Total Synthesis of Bioactive Peptides and Whole Proteins. Doctoral thesis, Durham University. Preview. PDF (S Lear - PhD Thesis, August 2016) - Accepted Version 16Mb: Abstract. Total chemical synthesis is an essential tool for the validation of natural product structures and the discovery and elaboration of novel therapeutic scaffolds. Chapter 1 (Part I) surveys existing.
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Vibrational Raman optical activity (ROA) which is the difference in the Raman scattering of left and right circularly polarised incident light, has recently emerged as a new and incisive probe of biomolecular structure. This thesis is based on new applications of ROA to some current biochemical problems. The first chapter is a brief explanation of the origin of chirality and the development of.
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Al-Wafi, Haider 2018. Synthesis and biological studies of cyclic peptides. PhD Thesis, Cardiff University. Item availability restricted.
PhD Thesis, T. Kean, Cardiff University, 2006 77. 2.3.10 Solid Phase Peptide Synthesis (SPPS) Solid phase peptide synthesis was performed using standard FMOC-based chemistry. The peptides u7 and Gu11G were prepared in the Univ Nijmegen by Dr M. Thanou.Cyclic peptides are class of emerging therapeutics, cargo delivery systems, and will afford you a vast knowledge in all of the biochemical.
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Peptides Phd Thesis. peptides phd thesis The Ronald Dubner Research Prize honors the best clinical or basic science research paper, series of papers, or doctoral thesis in the field of pain, published or in press, while in training as a student, intern, resident, predoctoral fellow, postdoctoral fellow, or equivalent.You are WELCOME!
ANTIMICROBIAL PEPTIDES FROM SNAKE AND SCORPION VENOM By Patrick Liam Harrison Submitted in partial fulfilment for the degree ofDoctor of Philosophy (PhD) Biomedical Research Centre, Sheffield Hallam University October 2014. Dedication This thesis is dedicated to the memory of Thomas O ’Shea and Trevor Harrison Very different men, who shared common decency, a belief in fairness and pride in.
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Discovery and characterization of novel bioac-tive peptides from marine secondary products Susan Skanderup Falkenberg PhD Thesis 2014. There is an increasing interest in bioactive peptides from marine secondary products, as they offer a great potential for incorporation into functional food and for medical purposes. Bioactive peptides from marine sources have been found to display a wide.
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